Successful treatment of carcinomatous meningitis with erlotinib and whole brain radiotherapy
نویسندگان
چکیده
منابع مشابه
Recovery from carcinomatous meningitis by erlotinib.
Treatment options include whole-brain irradiation, systemic chemotherapy, and intrathecal chemotherapy such as methotrexate [2]. Despite these measures, the prognosis is poor with a median survival of 2–3 months, and focal neurologic dysfunctions do not improve in most cases [1]. The benefit of EGFR tyrosine kinase inhibitors (TKIs) in the treatment of carcinomatous meningitis in patients with ...
متن کاملRandomized Trial of Erlotinib Plus Whole-Brain Radiotherapy for NSCLC Patients With Multiple Brain Metastases
BACKGROUND Median survival of non-small cell lung cancer (NSCLC) patients with brain metastases is poor. We examined concurrent erlotinib and whole brain radiotherapy (WBRT) followed by maintenance erlotinib in patients with untreated brain metastases, given the potential radiosensitizing properties of erlotinib and its direct effect on brain metastases and systemic activity. METHODS Eighty N...
متن کاملIntrathecal Methotrexate and Craniospinal Radiotherapy Can Be an Effective Treatment of Carcinomatous Meningitis in Patients with Breast Cancer: Case Reports
INTRODUCTION Carcinomatous meningitis in breast cancer occurs as a complication in up to 5% of all cases. It is a very devastating diagnosis, with a median patient survival of about 3 months. Treatment is very controversial, and different modalities of treatment have been used but none of them show significant benefit for overall survival. CASE REPORTS We report 2 cases of carcinomatous menin...
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The aim of this paper is to explore the efficacy of whole brain radiotherapy (WBRT) versus WBRT concurrent with erlotinib in patients with multiple brain metastases of lung adenocarcinoma. WBRT was administered at 30Gy/10f in both arms. In the combination arm, 150 mg erlotinib was given each day, starting the first day of radiotherapy and continuing for 1 month following the end of radiotherapy...
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Background: Palliative whole brain radiotherapy (WBRT) has been the standard treatment for brain metastases. Ionizing radiation is known to be one of the most potent cataractogenic agents. We aimed to evaluate two different radiotherapy techniques with respect to the doses received by the organs at risk (OAR) in patients with brain metastasis who undergone WBRT. Materials and Methods: Ten conse...
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ژورنال
عنوان ژورنال: Annals of Cancer Research and Therapy
سال: 2012
ISSN: 1344-6835,1880-5469
DOI: 10.4993/acrt.20.58